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Herbal Plethora For Management Of Neurodegenerative Disorders: An Invigorating Outlook

Author(s):

Garima Yadav, Tarique Mahmood Ansari*, Arshiya Shamim, Supriya Roy, Mohd Masih Uzzaman Khan, Farogh Ahsan, Mohammad Shariq, Saba Parveen and Rufaida Wasim  

Abstract:


Objective: Oxidative stress, proteasomal impairment, mitochondrial dysfunction, and accumulation of abnormal protein aggregates have shovelled a major section of senior population towards neurodegenerative disorders. Although age, genetic and environmental factors are thought to play a significant role, drug abuse is considered to be a potent trigger in Parkinsonism among the young generation. The present study is a critical examination on herbal resources for attenuation of neurodegeneration.

Materials and Methods: The following electronic databases have been used to search for literature: MEDLINE, Scopus, PubMed and EMBASE

Result: Paying heed to the prevalence in neurodegenerative disorders-Alzheimer’s & Parkinson’s; the current review encompasses the pathogenesis of neurodegeneration at cellular level and possible prospects to overcome the challenge sailing through the ocean of herbal boon. The United States-Alzheimer’s Association states, deaths attributable to heart disease in the country fell by 11% between 2000 and 2015, while deaths from neurodegenerative diseases increased by a staggering 123% making it, the world’s sixth leading cause of death. The irreversible pathological damage amounts to cognitive loss, dementia, Amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD) Alzheimer’s disease (AD). Various herbal drugs like Brahmi, Shankhpushpi and Amla are reported to be rich in phytoconstituents like, flavonoids, glycosides, alkaloids, fatty acids, sterols, tannins, saponins, and terpenes that have remarkable antioxidant potential and could be explored for the same to prevent neuronal necrosis.

Conclusion: It is also believed that herbal medicines are more effective and less toxic than synthetic drugs.

Keywords:

Antioxidant, Alzheimer's, Herbal drugs, Neurodegeneration, Oxidative stress, Parkinson's

Affiliation:

Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh 226026 , Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh 226026 , Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh 226026 , Amity Institute of Pharmacy, Amity University, Lucknow Campus, Uttar Pradesh 226028 , Department of Pharmaceutical Chemistry & Pharmacognosy, Unaizah college of Pharmacy, Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh 226026 , Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh 226026 , Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh 226026 , Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh 226026



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