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Does the Vitamin D Deficiency Have Any Role in Severity or Prolongation of Seizure? A Pilot Study in Iran

[ Vol. 16 , Issue. 5 ]


Mohammad Vafaee Shahi , Reza S. Badv , Alinaghi Kazemi , Samileh Noorbakhsh *, Koorosh Kamali, Shahin Teimourtash and Leila Tahernia   Pages 781 - 787 ( 7 )


Background :Based on previous studies, vitamin D deficiency could lead to nerve stimulation. The purpose of present study was to determine frequency and duration of seizuresin children with idiopathic epilepsy in two groups; normal level of vitamin D versus decreased level of vitamin D.

Methods: This pilot, comparativestudy wascarried outin Zanjan University of Medical Sciences on total 40 children aging between 2 to 12 years old(23 male and 17 female)with the diagnosis of idiopathic epilepsy.All patients were receiving anti-epileptic drugs. Initial questionnaire was completed by each parent.Total 40 epileptic cases were examined in close follow-ups every three months, during total 9 months. Meanwhile, the frequency and duration of each seizures were recorded in questionnaire in every three-month periods. Vitamin D blood samples were analyzed at thebeginning of the study andafter 9 months following the study. Serum levels of Vitamin D wereanalyzed by ELISA method(Elecsys2010,RocheCo,Germany ;STAR FAX; 2100), simultaneously, Vitamin D level <30 ng/ml(nanogram per milliliter) was defined as Vitamin D deficiency.Cases were divided in to two groups based on Vitamin D level. The frequency and duration of convulsions werecompared in patients with normal level of vitamin D Versus children with decreased level of vitamin D. Data were analyzed by Chi-square and t-test methods.

Results:In all 40 patients, vitamin D level less than 30ng/ml was detected in 32%(13 patients)at the beginning of study and %35(14 patients) in 9 months later(13 patients were common between two groups). There was no significant relationship between the frequency of seizures, the duration of seizures and vitamin D levels in patients. The relationship between positive family history of epilepsy and the number of seizures was reported significant. The frequency of vitamin D deficiency was higher in female cases in finalevaluation.

Conclusion: In present study, a considerable correlation was detected between the frequency of seizures and positive history of seizure in family. The frequency of vitamin D deficiencywas higher in female cases in finalanalysis.No significant relationship was detected between the number of seizures, the mean duration of seizures and serum level of Vitamin D in children who received anticonvulsant drugs. However, vitamin D deficiency in patients was not overlooked in order to prevent known complications. We recommend a randomized clinical trial in future with adequate sample size.Moreover, a non-epileptic control group in study would be useful.


Children, epilepsy, prolongation, seizure, severity, vitamin D.


Pediatric Growth and Development Research Center, Iran University of Medical Sciences, Tehran, Department of Pediatric Neurology, Tehran University of Medical, Sciences, Tehran, Pediatric and Member of Metabolic Disease Research Center, Zanjan University of Medical Sciences, Zanjan, Research Center of Pediatric Infectious Diseases, Rasul Akram Hospital, Iran University of Medical Sciences, Tehran, Statistics and Methodology, Member of Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Resident of Pediatrics, Zanjan University of Medical Sciences, Zanjan, Tehran University of Medical Sciences, Tehran

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