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Association Between Magnesium and Oxidative Stress in Patients with Obesity

[ Vol. 16 , Issue. 5 ]

Author(s):

Ana R.S. de Oliveira, Kyria J.C. Cruz, Jennifer B.S. Morais, Juliana S. Severo, Jessica B. Beserra, Loanne R. dos Santos, Stefany R. de Sousa Melo, Larissa M. Luz, Leidejaira A. de Sousa, Emidio M. de Matos Neto, Betania de Jesus e Silva de Almendra Freitas, Nadir do Nascimento Nogueira and Dilina do Nascimento Marreiro*   Pages 743 - 748 ( 6 )

Abstract:


Background: The role of minerals in preventing the generation of oxidative stress in obese individuals has been evaluated. Magnesium is an antioxidant nutrient and a cofactor of enzymes involved in the cell membrane stabilization, attenuating the effects of oxidative stress. Objective: To evaluate the association between magnesium and concentrations of thiobarbituric acid reactive substances (TBARS) in patients with obesity and eutrophic women. Method: A cross-sectional study was conducted with 73 women, divided into two groups: case group (patients with obesity, n=27) and control group (eutrophic women, n = 46). Measurements of body mass index and waist circumference were performed. Dietary magnesium intake was assessed by the three-day food record using the NutWin software. Urinary magnesium concentration was measured by atomic absorption spectrophotometry method. Plasma concentrations of thiobarbituric acid reactive substances (TBARS) were also determined. Results: Mean values of dietary magnesium intake were 161.59 ± 60.04 and 158.73± 31.96 for patients with obesity and control group, respectively, with no significant difference between the groups studied (p>0.05). The value of urinary excretion of magnesium was lower than the reference values in both groups, with no significant difference between the groups studied (p>0.05). The plasma concentration of thiobarbituric acid reactive substances was significantly higher in patients with obesity compared to the control group (p<0.001). There was no correlation between levels of magnesium biomarkers and the concentration of TBARS (p>0.05). Conclusion: Patients with obesity showed a reduced dietary magnesium intake which seems to induce hypomagnesuria as a compensatory mechanism. The marker of oxidative stress evaluated in this study was not influenced by magnesium.

Keywords:

Biomarkers, magnesium, nutritional status, obesity, oxidative stress, women.

Affiliation:

Departament of Nutrition, Federal Universityof Piauí, Minister Petrônio Portella Campus, Ininga, Teresina, Piauí, Departament of Nutrition, Federal Universityof Piauí, Minister Petrônio Portella Campus, Ininga, Teresina, Piauí, Departament of Nutrition, Federal Universityof Piauí, Minister Petrônio Portella Campus, Ininga, Teresina, Piauí, Departament of Nutrition, Federal Universityof Piauí, Minister Petrônio Portella Campus, Ininga, Teresina, Piauí, Departament of Nutrition, Federal Universityof Piauí, Minister Petrônio Portella Campus, Ininga, Teresina, Piauí, Departament of Nutrition, Federal Universityof Piauí, Minister Petrônio Portella Campus, Ininga, Teresina, Piauí, Departament of Nutrition, Federal Universityof Piauí, Minister Petrônio Portella Campus, Ininga, Teresina, Piauí, Departament of Nutrition, Federal Universityof Piauí, Minister Petrônio Portella Campus, Ininga, Teresina, Piauí, Departament o fNutrition, Federal Universityof Piauí, Minister Petrônio Portella Campus, Ininga, Teresina, Piauí, Departament of Physical Education, Federal Universityof Piauí, Minister Petrônio Portella Campus, Ininga, Teresina, Piauí, Departament of Nutrition, Federal Universityof Piauí, Minister Petrônio Portella Campus, Ininga, Teresina, Piauí, Departament of Nutrition, Federal Universityof Piauí, Minister Petrônio Portella Campus, Ininga, Teresina, Piauí, Departament of Nutrition, Federal Universityof Piauí, Minister Petrônio Portella Campus, Ininga, Teresina, Piauí



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