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The Effect of Vitamin C Supplementation on Cardiac Enzymes After Coronary Artery Bypass Graft: A Double-blind Randomized Control Trial

[ Vol. 16 , Issue. 5 ]

Author(s):

Jalal Moludi, Mohammad Alizadeh, Hamed Jafari-Vayghyan, Elaheh Foroumandi, Vahid Maleki, Behzad Ebrahimi, Anita Sadeghpour, Azin Alizadehasl and Ali S. Tabaee*   Pages 833 - 838 ( 6 )

Abstract:


Introduction: Coronary artery bypass graft (CABG) is associated with oxidative stress and tissue damage. Vitamin C, as an antioxidant agent, has an important role in attenuating the oxidative stress damage and might have cardio-protective effects after CABG. We aimed to evaluate the probable roles of Vitamin C supplementation on cardiac biomarkers after CABG.

Methods: In this randomized, control trial, 122 patients undergoing CABG were randomly assigned to the intervention (n=54) and control group (n=¬68) and received vitamin C (2 g intravenously) or placebo, respectively. The surgical methods of the patients in the two groups were identical. The primary efficacy endpoint of this trial is the difference in the levels of CK-MB, Troponin and Total Antioxidant Capacity (TAC) were measured at study entry and 24 hrs after surgery between two groups.

Results: The two groups were not significantly different in terms of basic variables. Within-group comparison showed significant rises in the level of troponin (P < 0.001) and CK-MB (P < 0.001) over time. However, between-group comparison showed no significant difference between the two groups in terms of CK-MB (P = 0.826) and troponin (P = 0.821). As a whole, the correlation between cardiac enzymes and surgical characteristic were not seen.

Conclusion: The results showed that pretreatment with vitamin C could not reduce cardiac marker following CABG. After intervention, TAC did not differ between and within the intervention and the control groups. Pretreatment with vitamin C as antioxidant agent could not reduce ischemic reperfusion resulting CABG.

Keywords:

Antioxidant, CABG, CKMB, reperfusion, troponin, vitamin C.

Affiliation:

Student Research Committee, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz,, Nutrition Research Center, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz,, School of Health, Arak University of Medical Sciences, Arak,, Student Research Committee, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Student Research Committee, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz,, Department of Food Science and Technology Maragheh University of Medical Science, Maragheh,, Echocardiography Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran,, Echocardiography Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran,, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran



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