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Insights into the Association of Vitamin D Deficiency with Parathyroid Hormone Levels with Relevance to Renal Function and Insulin Resistance

[ Vol. 15 , Issue. 2 ]

Author(s):

Iyyapu Krishna Mohan*, Siraj Ahmed Khan, Rachel Jacob, K.S.S. Sai Baba, Tajamul Hussain, Salman A Alrokayan and Shaik Mohammad Naushad   Pages 196 - 200 ( 5 )

Abstract:


Background: In majority of the studies inverse association between vitamin D and parathyroid hormone levels is documented.

Objective: The rationale of the current study was to investigate whether this inverse association is agedependent and whether it has any role in modulating renal function and insulin resistance.

Methods: To test this hypothesis, we have carried out a hospital based study enrolling 848 subjects (558 men and 290 women) with the mean age of 50.9±15.9 y. Chemiluminometric competitive immune assays were performed using commercial kits to determine 25-OH vitamin D and parathyroid hormone (PTH) levels. Fasting glucose levels and serum creatinine were used to evaluate diabetes and renal function.

Results: Vitamin D deficiency was predominant irrespective of age group (p=0.21) and gender (p=0.12). An inverse association between vitamin D and PTH was observed (r= -0.24) in middle age subjects (p=0.02). The data segregation based on plasma vitamin D levels which were <20 ng/ml, 20.1-30 ng/ml and >30 ng/ml confirmed the inverse association between vitamin D and PTH levels (ptrend: 0.007). Subjects with low plasma vitamin D and increased PTH exhibited elevated blood urea, serum creatinine and blood glucose. Subjects with 25-OHD deficiency showed a 3.03-folds (95% CI: 2.26-4.07) and 2.09-fold (1.41-3.10) increased risk for diabetes and renal disease, respectively.

Conclusion: Based on the results of the present study, it is suggested that those with vitamin D deficiency need to be evaluated for possible presence of renal dysfunction, diabetes/insulin resistance in addition to assessing their PTH status.

Keywords:

Diabetes, hyperparathyroidism, insulin resistance, parathyroid hormone, vitamin D.

Affiliation:

Department of Biochemistry, Nizam’s Institute of Medical Sciences, Panjagutta, Hyderabad-500082, Department of Biochemistry, Nizam’s Institute of Medical Sciences, Panjagutta, Hyderabad-500082, Department of Biochemistry, Nizam’s Institute of Medical Sciences, Panjagutta, Hyderabad-500082, Department of Biochemistry, Nizam’s Institute of Medical Sciences, Panjagutta, Hyderabad-500082, Center of Excellence in Biotechnology Research, King Saud University, PO Box 2455, Riyadh, 11451, Department of Biochemistry, College of Science, King Saud University, PO Box 2455, Riyadh, 11451, Department of Biochemical Genetics, Sandor Life sciences Pvt Ld, Banjara Hills, Hyderabad-500034



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