Submit Manuscript  

Article Details


Acute Administration of Nigella sativa Showed Anxiolytic and Anti- Depression Effects in Rats

[ Vol. 14 , Issue. 5 ]

Author(s):

Farimah Beheshti, Fatemeh Norouzi, Azam Abareshi, Akbar Anaeigoudari and Mahmoud Hosseini*   Pages 427 - 436 ( 10 )

Abstract:


Objective: Nigella sativa (NS) has been shown to have some effects on the central nervous system. In the present work, anxiolytic and anti- depression effects of an acute administration of hydro- alcoholic extract of NS was investigated in rats.

Materials and Methods: The rats were grouped and treated 30 min before conducting the behavioral tests: (1) saline as a control group, (2-4) three groups including NS 100, NS 200 and NS 400 treated by three doses (100, 200 and 400 mg/ kg) of NS. The animals were examined using Forced Swim Test (FST), Open-Field (OFT) and Elevated Plus Maze (EPM) tests.

Results: NS extract improved the time spent, crossing number and traveled distance in the central zone in OFT compared to the control group (p<0.01- p<0.001). The time spent in the peripheral area of OFT by all animals’ treated groups was lower than that of control group (p<0.01 and p<0.001). Compared to the control group, all three extract treated groups showed greater total crossing and total traveled distance in OFT (p<0.05-p<0.001). Compared to the control group, the animals treated by 200 and 400 mg/kg of NS spent longer times in the open arm of EPM (p<0.05 and p<0.001). All three doses of the extract shortened the closed arm entries compared to the control group (p<0.001). The animals of NS 200 and NS 400 groups spent lower times in the closed arm compared to the control group (p<0.01 and p<0.05). In FST, the immobility times in the NS 400 group were lower than control (p<0.05). All three doses of the plant extract increased the climbing times compared to the control group (p<0.01 - p<0.001).

Conclusion: The results of the present work demonstrated that acute administration of the hydroalcoholic extract of NS had anxiolytic and anti-depression effects in rats. More advanced examinations are needed for better comprehension of the responsible compound(s) and mechanism(s).

Keywords:

Anxiety, anxiolytic, central nervous system, depression, Nigella sativa, rats.

Affiliation:

Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Mashhad, Department of Physiology, Esfarayan Faculty of Medical Sciences, Esfarayan, Iran Esfarayan, Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Mashhad, Department of Physiology, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran Jiroft, Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Mashhad



Read Full-Text article