Snehal S. Patel, Rajendra S. Shah and Ramesh K. Goyal Pages 57 - 62 ( 6 )
Introduction: The present investigation was carried out to study antihyperglycemic activity of formulation prepared by spray-dried powder of fruit juice of E. officinalis (SDF) on animal model of type 1 diabetes.Methods: Hyperglycemia was produced by streptozotocin 45 mg/kg i.v. and formulation was administered orally (100 mg/kg) for 28 days to diabetic rats. At the end of 28 days various biochemical parameters such as serum glucose, insulin, AUCglucose, AUC insulin and lipid profile were estimated. Results: STZ induced rats showed signs and symptoms of diabetes such as body weight loss, polydipsia, polyuria, polyphagia, treatment with formulation produced slight improvement in these symptoms. Treatment with formulation to diabetic rat produced significant decrease in serum glucose, AUCglucose, triglyceride, cholesterol, LDL cholesterol, VLDL cholesterol. However, insulin, AUCinsulin and serum high density lipoprotein level were not significantly affected after treatment. Treatment also produced reduction in malonaldehyde levels and increased antioxidant enzymes levels in diabetic rats. Conclusion: Thus, formulation of E. officinalis significantly improved glucose and lipid dysfunction and oxidative stress in diabetic status. The mechanism of its antidiabetic activity may be either increase in peripheral glucose uptake, reduced insulin resistance or antioxidant property of formulation.
Antidiabetic, antihyperlipidemic, antioxidant, fruit juice, oxidative stress.
Vice Chancellor, Delhi Pharmaceutical Sciences and Research University, Delhi 110017